The crash was on I-81 South around mile marker 82.5, PennDOT's Thompson said in a statement at 12:16 p.m.
The interstate is closed at Exit 85 - Route 934/Annville/Ft Indiantown Gap.
"The closure is expected to last a while," Thompson said.
The roadway reopened at 6:18 p.m., a spokesperson told us in an update statement.
There was no word on any injuries, or how the crash happened.
Check back here for updates.
Click here to follow Daily Voice West Grove-Avondale and receive free news updates.